Bortezomib-induced peripheral neurotoxicity: still far from a painless gain.
نویسندگان
چکیده
منابع مشابه
Bortezomib-induced painful neuropathy in patients with multiple myeloma
Neurotoxicity towards the peripheral nervous system which appears clinically in the form of painful neuropathy is an essential dose-limiting factor during the treatment of multiple myeloma. In this review article different forms of this painful neuropathy are presented together with currently available diagnostic tools which are usually applied to confirm the diagnosis. Also, the most often use...
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In multiple myeloma, peripheral neuropathy has for a long time been considered as mainly secondary to the plasma cell dyscrasia itself. With the advent of new targeted drugs such as thalidomide and bortezomib, the iatrogenic neurotoxicity has become the leading cause of peripheral neuropathy. This review discusses the pathogenesis, incidence, risk factors, diagnosis, characteristics, and manage...
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Peripheral neurotoxicity is a dose-limiting and disabling side effect of several important chemotherapeutic agents. In particular, vincristine, cisplatin, oxaliplatin, paclitaxel, and docetaxel are frequently used antineoplastic agents, which are known causes of a peripheral neuropathy. The recently registered proteasome inhibitor bortezomib, which is effective in multiple myeloma, is the lates...
متن کاملPrevention of Chemotherapy-Induced Neuropathy: Leukemia Inhibitory Factor
Peripheral neurotoxicity is a dose-limiting and disabling side effect of several important chemotherapeutic agents. In particular, vincristine, cisplatin, oxaliplatin, paclitaxel, and docetaxel are frequently used antineoplastic agents, which are known causes of a peripheral neuropathy. The recently registered proteasome inhibitor bortezomib, which is effective in multiple myeloma, is the lates...
متن کاملElectroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy in multiple myeloma: a feasibility study
BACKGROUND This single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma. METHODS Patients with neuropathy ≥ grade 2 received 20 acupuncture treatments over 9 weeks. RESULTS For the 19 evaluable patients, Functional Assessment of Cancer Therapy/Gynecologic...
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عنوان ژورنال:
- Haematologica
دوره 92 10 شماره
صفحات -
تاریخ انتشار 2007